Program

Ataxia-Telangiectasia Workshop 2019 (ATW2019): Taking a Multidisciplinary Approach

Chair:  Tej K. Pandita, PhD, Houston Methodist

Co-chair:  Junjie Chen, PhD, MD Anderson Cancer Center, Houston, TX

Yosef Shiloh, PhD, Tel Aviv University, Israel – “Ataxia-Telangiectasia: Are We Closer to Understanding the Ataxia?”

Andre Nussenzweig, PhD, National Cancer Institute, NIH, USA – “How ATM Regulates End Resection”

Ralph Scully, PhD, Harvard Medical School, Boston, MA – “Recombination and Repair at Stalled Mammalian Replication Forks”

Daniel Durocher, PhD, University of Toronto, Ontario, Canada – “Charting the Genetic Architecture of the DNA Damage Response”

Dipanjan Chowdhury, PhD, Dana-Farber Cancer Institute, Boston, MA – “A Novel CDK5-PP4 Phospho-Signaling Cascade Regulates Genome Stability During Cell Cycle”

Junjie Chen, PhD, MD Anderson Cancer Center, Houston, TX – “Targeting DNA Damage Checkpoint in Cancer Therapy”

Shyamal Desai, PhD, LSUHSC-School of Medicine, New Orleans, LA – “Deregulation of Mitophagy by Ubiquitin-like Proteins in Ataxia-Telangiectasia”

Vijaya Charaka, PhD, Houston Methodist – “The HP1β Chromo Shadow Domain Assists BRCA1 Recruitment by Promoting H2A Ubiquitination”

Peter McKinnon, PhD, St. Jude Children’s Research Hospital, Memphis, TN – “ATM Suppresses Cerebellar Ataxia by Preventing Toxic NHEJ”

Katherine Schlacher, PhD, MD Anderson Cancer Center, Houston, TX – “Mitochondrial and Nuclear DNA Replication Instability in Disease”

Philip J. Horner, PhD, Houston Methodist – “Neuromodulation and Cell Engineering to Replace Damaged Brain Circuitry”

Martin F. Lavin, PhD, University of Queensland, Brisbane, Australia – “Defective Endoplasmic Reticulum (ER)-Mitochondrial Signaling in A-T”

Ari Barzilai, PhD, Tel Aviv University, Israel – “The Role of ATM in Cerebellar Structure-function”

John Cooke, MD, PhD, Houston Methodist – “Possible Role of Transflammation in Ataxia-Telangiectasia Syndrome”

Tetsuo Ashizawa, MD, Houston Methodist – “Ataxia and ATM”

Zhao-Qi Wang, PhD, Leibniz Institute for Age Research, Germany – “Biological Function of ATR”

Kalpana Mujoo, PhD, Houston Methodist – “DNA Damage Repair by Homologous Recombination is Decreased in Human Pluripotent Stem Cell Derived Differentiated Cells, Astrocytes and Dopaminergic Neurons”

Simon Powell, MD, PhD, FRCP, Memorial Sloan Kettering Cancer Center, New York, NY – “The Impact of ATM Mutations on Cancer Genomes and Response to Therapy”

James Larner, MD, University of Virginia, Charlottesville, VA – “A Novel Role for ZEB1 in Promoting NHEJ”

Kum Kum Khanna, PhD, Queensland Institute for Medical Research, Australia – “Sensitizing Cancer Stem Cells to Radio- and Chemotherapy”

Shashank Hambarde, PhD, Houston Methodist – “Exonuclease 5 Interacts with the BLM Helicase Complex and Protects the Genome from Replication Stress”

Chi-Lin Tsai, PhD, MD Anderson Cancer Center, Houston, TX – “[4Fe-4S] Cluster-containing Human Exonuclease V Acts as a Novel Replication Fork Restart Factor”

Tanya Paull, PhD, University of Texas at Austin, TX – “Consequences of ATM Loss in Human Cells”

Christopher Bakkenist, PhD, University of Pittsburgh, PA – “DNA Damage Signaling to Dormant Origins of Replication”

Lisa Bouchier-Hayes, PhD, Baylor College of Medicine, Houston, TX – “Caspase-2 Regulates S-phase Checkpoint Activation to Facilitate DNA Repair”

Nayan Kim, PhD, University of Texas Health Science Center at Houston – “Nucleolin and the Genome Instability Associated with G4 DNA”

Marguerite Blignaut, PhD, Stellenbosch University, Tygerberg, South Africa – “Ataxia-Telangiectasia Mutated is Located in Cardiac Mitochondria and Impacts Oxidative Phosphorylation”

Ji-Hoon Lee, University of Texas at Austin, TX – “The Role of Single-Stranded DNA Breaks and Parylation in A-T and ATLD Phenotypes”

Jacques Cote, PhD, Laval University Cancer Research Center, Quebec City, Canada – “The Importance of Lysine Acetyltransferase Complexes in the Repair of DNA Double Strand Breaks”

Tej K. Pandita, PhD, Houston Methodist – “Pre-existing H4K16ac Levels in Euchromatin Drive DSB Repair by Homologous Recombination”

Subhrangsu Mandal, PhD, The University of Texas at Arlington – Long Noncoding RNA in Neuro-Inflammation and Neurological Disorders”

Yang Yu, PhD, Baylor College of Medicine, Houston, TX – “DNA2 Nuclease Deficiency Results in Large and Complex DNA Insertions at Chromosomal Breaks”

Michele Menotta, PhD, University of Urbino “Carlo Bo”, Urbino, Italy – “A New HDAC4 Role, Induced by Dexamethasone, Improves Autophagy in A-T Cells”

Young Don Kwak, PhD, St. Jude Children’s Research Hospital, Memphis, TN  – “R-Loops and Aberrant Rna Splicing Impact Cerebellar Purkinje Cells in Genome Instability-Induced Neurodegeneration”

Alexander James Roy Bishop, DPhil, University of Texas Health Science Center at San Antonio – “ATM: Intrinsic Control of Amino Acid Metabolism and Disease Manifestation”

Benu Brata Das, PhD, Indian Association for the Cultivation of Science, Jadavpur Kolkata, India – “New Regulators of DNA Topoisomerase 1-induced DNA Damage and Repair”

Junran Zhang, MD, PhD, Ohio State University, Columbus, OH – “Exploring Potential Biomarkers Predictive of Response to Inhibitors Targeting Cell Cycle Checkpoint Proteins ATR and CHK1”

Barbara Huisamen, PhD, Stellenbosch University, Tygerberg, South Africa – “ATM Regulates Cardiac Mitophagy”

Anastasia Ricci, PhD, University of Urbino “Carlo Bo,” Urbino, Italy – “Lamin A/C Interactome Modulated by Dexamethasone in A-T Cells”

Aditi, PhD, St. Jude Children’s Research Hospital, Memphis, TN – “Ribonuclease H2 is Required for the Maintenance of Genomic Integrity During Neurogenesis and Prevention of Brain Tumors”

Stoyno Stoynov, PhD, Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria – “Dynamics of ATM, ATR and Their Substrates in Complex DNA Lesions”

John Tainer, MD Anderson Cancer Center, Houston, TX – “MRE11 Complex Control and the A-T Phenotype”

Maria Jasin, PhD, Memorial Sloan Kettering Cancer Center, New York, NY – “ATM Deficiency and the Impact on Meiotic Recombination”

Sagar Sengupta, PhD, National Institute of Immunology, India – “Multiple Repair Mechanisms Employed by BLM Helicase to Maintain Genome Integrity”

Karen Vasquez, PhD, University of Texas at Austin – “Targeting the High Mobility Group Box 3 Protein Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin”

Roketa Sloan Henry, PhD, St Jude Children’s Research Hospital, Memphis, TN – “ATM Suppresses Ataxia by Preventing Toxic NHEJ after Aberrant Topoisomerase I Activity”

Jessica Luzwick, PhD,  MD Anderson Cancer Center, Houston, TX – “Mitochondrial DNA Replication Fork Protection by the Fanconi Anemia Pathway Suppresses Inflammation and Disease”

Cheryl Lyn Walker, Baylor College of Medicine, Houston, TX – “An AMPK-regulated Energy Pathway that Directs ATM Localization to the Peroxisome”

Varsha Gandhi, PhD, MD Anderson Cancer Center, Houston, TX – “Mitochondrial Dysfunction and Inhibition of Mitophagy in Mantle Cell Lymphoma Lacking ATM”

Xingzhi (Xavier) Xu, PhD, Shenzhen University, Guangdong, China – “MRE11 UFMylation Promotes ATM Activation”

Sukesh R. Bhaumik, PhD, Southern Illinois University School of Medicine, Springfield, IL – Regulatory Mechanisms of Transcription-coupled DNA Repair”

Zhenkun Lou, PhD, Mayo Clinic, Rochester, MN – “Ubiquitin Signaling in the DNA Damage Response”

Sathees C. Raghavan, PhD, Indian Institute of Science, Bangalore, India – “Sequence Dependence of Nonhomologous End Joining and Alternate Pathways to DNA Double-strand Break Repair”

Aloke Sarkar, PhD, MD Anderson Cancer Center, Houston, TX – “Kinase Independent ATM-Parkin Interaction Drives Mitochondrial Autophagy in Mantle Cell Lymphoma”

K. Munniyapa, PhD, Indian Institute of Science, Bangalore, India – “Physiologically Important Small Molecules as Regulators of RecA Function”

Jeremy Stark, PhD, City of Hope, Duarte, CA – “Etiology of Chromosomal Rearrangements”

Rashmi Shukla, PhD, All India Institute of Medical Sciences, New Delhi, India – “Novel Pathogenic ATM Variants in Indian Ataxia Telangiectasia Patients”

Marina Alfo, PhD, Tel Aviv University, Israel – “Investigation of the Cerebellar Degeneration in Ataxia-Telangiectasia Using Mouse Models with Combined ATM and SETX Genotypes”

Meredith Juncker, PhD, LSUHSC-School of Medicine, New Orleans, LA – “ISG15 Inhibits Mitophagy in Ataxia-Telangiectasia”

Shan Zha, MD, PhD, Columbia University, New York, NY – “The Consequence of ATM Inactivation and Beyond”

Nhung Pham, PhD, Baylor College of Medicine, Houston, TX – “Rad52 and Rad59 Annealing Activity Suppress DNA Breaks Repair Via Mutagenic Break-Induced Replication”

James E. Haber, PhD, Brandeis University, Waltham, MA – “Autoregulation of Budding Yeast ATR and the Dynamics of ATM/ATR-dependent Chromatin Modification”